Brand Names: Vytorin
What is Vytorin?
Vytorin contains a combination of ezetimibe and simvastatin.
Vytorin is used to treat excessive ldl cholesterol in adults and children who're no less than 10 years old.
Ezetimibe reduces the quantity of cholesterol absorbed by the body.
Simvastatin is in a bunch of drugs known as HMG CoA reductase inhibitors, or "statins." Simvastatin reduces ranges of "dangerous" ldl cholesterol (low-density lipoprotein, or LDL) and triglycerides within the blood, whereas increasing ranges of "good" cholesterol (high-density lipoprotein, or HDL).
Vytorin may additionally be used for functions not listed in this remedy guide.
Vital information about Vytorin
You should not take Vytorin if you are allergic to ezetimibe and simvastatin, if you have liver disease, or if you are pregnant or breast-feeding. In uncommon cases, simvastatin can trigger a situation that ends in the breakdown of skeletal muscle tissue, leading to kidney failure. Name your doctor right away when you've got unexplained muscle pain, tenderness, or weak point especially in case you even have fever, uncommon tiredness, and dark coloured urine.
Never take Vytorin in bigger quantities, or for longer than really useful by your doctor. Observe your physician's dosing directions very carefully. Taking too much Vytorin may cause severe or life-threatening facet effects.
There are lots of different drugs that should not be used along with Vytorin. Tell your doctor about all drugs you use. Hold an inventory of all your medicines and present it to any healthcare supplier who treats you.
Before taking Vytorin, tell your doctor in case you have ever had liver or kidney disease, diabetes, or a thyroid dysfunction, if you are of Chinese language descent, or when you drink greater than 2 alcoholic drinks daily.
Vytorin can harm an unborn baby or trigger delivery defects. Don't use if you are pregnant.
Grapefruit and grapefruit juice could work together with simvastatin and lead to probably dangerous effects. Don't drink more than 1 quart of grapefruit juice daily.
Before taking Vytorin
You should not take Vytorin if you're allergic to ezetimibe or simvastatin, if you have liver disease, or if you are pregnant or breast-feeding. In rare circumstances, simvastatin can cause a condition that leads to the breakdown of skeletal muscle tissue, resulting in kidney failure. This situation could also be extra more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). You might also be extra prone to develop this situation in case you are of Chinese descent and you're taking high-dose Vytorin whereas additionally taking medicine that contains niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others).
The following drugs can improve your danger of great muscle issues if you happen to take them together with simvastatin. These medicine should not be used if you are taking Vytorin:
- cyclosporine (Gengraf, Neoral, Sandimmune);
- danazol (Danocrine);
- gemfibrozil (Lopid);
- nefazodone (an antidepressant);
- the antibiotics clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), and telithromycin (Ketek);
- the antifungal drugs itraconazole (Sporanox), ketoconazole (Nizoral), and posaconazole (Noxafil); or
- the HIV/AIDS medications atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), saquinavir (Invirase), and tipranavir (Aptivus).
Before you start taking Vytorin, inform your doctor in case you are already using any of those different medicines:
- amiodarone (Cordarone, Pacerone);
- amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide);
- diltiazem (Cartia, Cardizem);
- ranolazine (Ranexa); or
- verapamil (Calan, Covera, Isoptin, Verelan).
To ensure you can safely take Vytorin, inform your doctor if you have any of those other situations:
- history of liver illness;
- historical past of kidney disease;
- diabetes;
- a thyroid dysfunction; or
- for those who drink more than 2 alcoholic beverages daily.
FDA being pregnant category X. Vytorin can harm an unborn child or trigger delivery defects. Don't take Vytorin if you're pregnant. Cease taking this treatment and inform your physician right away should you develop into pregnant. Use effective contraception to avoid pregnancy while you're taking Vytorin. Ezetimibe and simvastatin could move into breast milk and will harm a nursing baby. Don't breast-feed while you are taking Vytorin.
How should I take Vytorin?
Take Vytorin exactly as prescribed. By no means take this medication in bigger quantities, or for longer than advisable by your doctor. Follow your physician's dosing directions very carefully. Taking too much of Vytorin could trigger critical or life-threatening aspect effects.
Vytorin is normally taken as soon as every day within the night, with or with out food. Your doctor might sometimes change your dose to ensure you get the best results.
To be sure Vytorin helps your situation and isn't causing harmful effects, your blood will should be tested often. Your liver perform should be examined each three to six months. Visit your physician regularly. It's possible you'll have to take Vytorin on a long-time period foundation for the remedy of high cholesterol. It's possible you'll need to cease using Vytorin for a short while when you have surgical procedure or a medical emergency. Don't cease taking Vytorin until your doctor tells you to.
Vytorin is just a part of an entire program of treatment that additionally includes weight loss plan, exercise, and weight control. Observe your weight loss program, remedy, and exercise routines very closely.
Store Vytorin at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.
What occurs if I miss a dose?
Take the missed dose as quickly as you remember. Skip the missed dose whether it is virtually time on your subsequent scheduled dose. Don't take further medication to make up the missed dose.
What occurs if I overdose?
Search emergency medical attention or name the Poison Help line at 1-800-222-1222.
What should I keep away from while taking Vytorin?
Grapefruit and grapefruit juice may interact with simvastatin and result in potentially dangerous effects. Don't drink more than 1 quart of grapefruit juice daily.
For those who additionally take cholestyramine (Prevalite, Questran) or colestipol (Colestid), avoid taking them inside 2 hours after or four hours before you're taking Vytorin.
Avoid eating meals which can be excessive in fat or cholesterol. Vytorin will not be as efficient in lowering your cholesterol if you don't observe a ldl cholesterol-reducing weight loss plan plan.
Keep away from ingesting alcohol. It can raise triglyceride levels and should improve your threat of liver damage.
Vytorin uncomfortable side effects
Get emergency medical help you probably have any of these indicators of an allergic response to Vytorin: hives; issue respiratory; swelling of your face, lips, tongue, or throat.
Stop taking Vytorin and name your physician at once when you've got any of those severe unwanted side effects:
- unexplained muscle pain, tenderness, or weak spot;
- fever, unusual tiredness, and darkish coloured urine;
- swelling, weight acquire, urinating less than ordinary or by no means;
- chest ache, dry cough, wheezing, feeling wanting breath;
- severe ache in your higher abdomen spreading to your back, nausea and vomiting, quick heart price; or
- nausea, upper abdomen ache, itching, loss of urge for food, darkish urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Much less severe Vytorin negative effects may embody:
- headache, reminiscence problems, dizziness, depressed mood;
- again pain, joint ache, gentle muscle ache;
- numbness or tingly feeling;
- trouble having an erection;
- diarrhea;
- sleep issues (insomnia); or
- chilly symptoms resembling stuffy nostril, sneezing, sore throat.
This isn't an entire checklist of unintended effects and others might occur. Call your doctor for medical advice about aspect effects. You could report unwanted side effects to FDA at 1-800-FDA-1088.
What other medication will have an effect on Vytorin?
Inform your doctor about all other medicines you employ, particularly:
- colchicine (Colcrys);
- digoxin (Lanoxin);
- a blood thinner akin to warfarin (Coumadin, Jantoven);
- fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide);
- antifungal drugs reminiscent of fluconazole (Diflucan) or voriconazole (Vfend);
- medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
- medication that weaken your immune system, such as steroids, cancer medicine, or medicines used to stop organ transplant rejection, equivalent to sirolimus (Rapamune), or tacrolimus (Prograf); or
- any other "statin" treatment resembling atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Altoprev, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or different medication that incorporates simvastatin (Simcor, Zocor).
This record will not be full and there are lots of different medication that can cause severe or life threatening medical issues should you take them along with Vytorin. Tell your doctor about all medicines you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not begin a new medication without telling your doctor. Preserve a listing of all your medicines and show it to any healthcare provider who treats you.
Where can I get extra information?
Your pharmacist can present extra details about Vytorin.
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