Brand Names: Aplenzin, Budeprion, Wellbutrin, Zyban
What is Wellbutrin?
Wellbutrin (bupropion) is an antidepressant medication. It works within the mind to deal with depression.
Wellbutrin is used to treat major depressive disorder and seasonal affective disorder. No less than one model of bupropion (Zyban) is used to help individuals stop smoking by lowering cravings and other withdrawal effects.
Wellbutrin may additionally be used for different functions not listed on this medication guide.
Important details about Wellbutrin
Don't take Wellbutrin if you have taken a monoamine oxidase inhibitor (MAOI) similar to furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the final 14 days. You should not take Wellbutrin if you have seizures, an consuming disorder, if you're utilizing a second type of bupropion, or when you have abruptly stopped using alcohol or sedatives.
Wellbutrin may trigger seizures, especially in folks with certain medical situations or when using certain drugs. Tell your physician about all your medical situations and the medicine you use.
You might have thoughts about suicide once you first begin taking an antidepressant resembling Wellbutrin, particularly in case you are youthful than 24 years old. Your physician will need to check you at common visits for at the very least the first 12 weeks of treatment.
Report any new or worsening signs to your physician, resembling: temper or conduct changes, nervousness, panic assaults, hassle sleeping, or in case you feel impulsive, irritable, agitated, hostile, aggressive, stressed, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Avoid drinking alcohol whereas taking Wellbutrin. It could enhance your danger of seizures.
Before taking Wellbutrin
Do not take Wellbutrin if you have taken a monoamine oxidase inhibitor (MAOI) equivalent to furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) within the last 14 days.
You should not take Wellbutrin if in case you have:
- epilepsy or a seizure disorder;
- an eating disorder akin to anorexia or bulimia;
- if you are utilizing a second form of bupropion; or
- in case you have instantly stopped utilizing alcohol or sedatives (resembling Valium).
Wellbutrin might cause seizures, particularly in folks with sure medical conditions. Tell your physician about your entire medical conditions.
If in case you have any of these different circumstances, your physician might have to regulate your Wellbutrin dosage or order particular assessments:
- a historical past of head harm, seizures, or mind or spinal wire tumor;
- coronary heart illness, hypertension, history of heart assault;
- kidney illness;
- liver disease (especially cirrhosis); or
- bipolar dysfunction (manic despair).
You might have ideas about suicide if you first begin taking an antidepressant equivalent to Wellbutrin, especially in case you are youthful than 24 years old. Tell your doctor in case you have worsening symptoms of despair or suicidal ideas in the course of the first a number of weeks of remedy, or every time your dose is changed.
Your family or other caregivers should even be alert to adjustments in your mood or symptoms. Your physician will need to check you at regular visits for at the least the first 12 weeks of remedy with Wellbutrin.
FDA pregnancy class C. It isn't known whether or not Wellbutrin will harm an unborn baby. Tell your doctor if you are pregnant or plan to develop into pregnant whereas utilizing Wellbutrin. Bupropion passes into breast milk and could be harmful to a nursing baby. You should not breast-feed when you are taking Wellbutrin.
How should I take Wellbutrin?
Take Wellbutrin exactly as prescribed by your doctor. Do not soak up larger or smaller quantities or for longer than recommended. Follow the directions in your prescription label.
Your doctor might occasionally change your dose to be sure to get the best results.
Wellbutrin can be taken with or with out food.
Don't crush, chew, or break an extended-launch tablet. Swallow it whole. Breaking the capsule could cause too much of the drug to be launched at one time, which might enhance unwanted effects together with seizures.
Don't cease taking Wellbutrin without first talking to your doctor. You'll have unpleasant unintended effects in case you cease taking this treatment suddenly.
Should you use the Wellbutrin prolonged-release tablet, the pill shell might pass into your stools (bowel actions). That is regular and doesn't imply that you are not receiving enough of the medicine.
Wellbutrin can trigger you to have a false constructive drug screening test. Should you present a urine pattern for drug screening, inform the laboratory workers that you are taking bupropion.
Store Wellbutrin at room temperature away from moisture and heat.
What occurs if I miss a dose?
Take the missed dose as quickly as you remember. Skip the missed dose if it is virtually time to your next scheduled dose. Don't take additional drugs to make up the missed dose.
What occurs if I overdose?
Search emergency medical consideration or name the Poison Assist line at 1-800-222-1222. An overdose of Wellbutrin can be fatal. Overdose symptoms may embody muscle stiffness, hallucinations, quick or uneven heartbeat, shallow respiratory, or fainting.
What should I avoid while taking Wellbutrin?
Drinking alcohol may increase your risk of seizures. In case you drink alcohol regularly, talk with your physician before altering the quantity you drink. Wellbutrin can trigger seizures in individuals who drink plenty of alcohol and then all of the sudden stop consuming once they begin using the medication.
Avoid utilizing bupropion to deal with multiple condition at a time. If you take Wellbutrin for despair, do not also take Zyban to quit smoking. Too much of this medicine can increase your threat of a seizure.
Wellbutrin could impair your considering or reactions. Be careful if you drive or do anything that requires you to be alert.
Wellbutrin side effects
Get emergency medical help when you've got any of these indicators of an allergic reaction to Wellbutrin: hives; difficulty respiratory; swelling of your face, lips, tongue, or throat.
Report any new or worsening signs to your doctor, resembling: temper or habits changes, anxiety, panic assaults, trouble sleeping, or for those who feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), extra depressed, or have thoughts about suicide or hurting yourself.
Call your physician without delay you probably have a severe facet impact while taking Wellbutrin resembling:
- seizure (convulsions);
- extreme blistering, peeling, and pink skin rash;
- fever, swollen glands, rash or itching, joint pain, or general ill feeling;
- confusion, bother concentrating; or
- hallucinations, uncommon ideas or behavior.
Much less serious Wellbutrin negative effects could embody:
- headache or migraine;
- sleep problems (insomnia);
- nausea, vomiting, constipation, dry mouth;
- dizziness, tremors (shaking);
- urge for food adjustments, weight loss or acquire;
- mild itching or skin rash, elevated sweating; or
- lack of interest in sex.
This is not a complete listing of uncomfortable side effects and others may occur. Call your doctor for medical advice about facet effects. You may report side effects to FDA at 1-800-FDA-1088.
Wellbutrin Dosing Information
Standard Grownup Wellbutrin Dose for Melancholy:
Rapid release tablets:
Preliminary dose: a hundred mg orally twice a day.
Upkeep dose: The dosage could also be increased in 75 to 100 mg/day increments no more usually than each 3 days up to the standard upkeep dose of a hundred mg orally three instances a day. The maximum dose is 450 mg/day, given in 4 divided doses; Wellbutrin should be discontinued if there may be not an ample response to this dose. Single doses should not exceed one hundred fifty mg.
Sustained release tablets:
Preliminary dose: 150 mg orally as soon as a day within the morning.
Upkeep dose: After not less than 4 days, the dose may be increased to a hundred to a hundred and fifty mg twice a day. If there is not satisfactory improvement after a number of weeks, the dose could also be elevated to a maximum of 200 mg twice a day.
Extended release tablets (Wellbutrin XL):
Initial dose: a hundred and fifty mg orally once a day in the morning.
Maintenance dose: After at least four days, the dose could also be increased to 300 mg once a day. If there is not adequate improvement after a number of weeks, the dose may be increased to a most of 450 mg as soon as a day in the morning.
Typical Grownup Wellbutrin Dose for Seasonal Affective Dysfunction:
Extended-release:
Initial: one hundred fifty mg orally once a day in the morning
Titration: If tolerated, after 7 days dose may be elevated to maximum dose of four hundred mg as soon as a day administered in the morning. Sufferers who're unable to tolerate this increase in dose should be lowered again to a hundred and fifty mg orally once a day.
Ordinary Geriatric Dose for Melancholy:
Preliminary dose: seventy five mg orally twice a day.
Upkeep dose: seventy five mg orally 3 times a day.
Maximum doses:
Immediate Release: a hundred and fifty mg orally 3 times a day.
Sustained Launch: four hundred mg given as 200 mg twice a day.
Common Pediatric Wellbutrin Dose for Consideration Deficit Dysfunction:
Rapid release tablets:
6 to 18 years:
20 to 30 kg: 50 to a hundred and fifty mg/day in 2 divided doses (investigational).
31 to forty kg: seventy five to 200 mg/day in 2 divided doses (investigational).
Higher than 40 kg: 100 to 250 mg/day in 2 divided doses (investigational).
Extended launch tablets:
Less than 11 years: Security and effectiveness haven't been established.
11 to 18 years: a hundred and fifty to 300 mg/day in 2 divided doses (investigational).
What other drugs will affect Wellbutrin?
Many medicine can work together with Wellbutrin. Below is just a partial list. Inform your physician in case you are using:
- treatment used to prevent blood clots, such as clopidogrel (Plavix) or ticlopidine (Ticlid), tirofiban (Aggrastat);
- cancer drugs such as cyclophosphamide (Cytoxan, Neosar), doxorubicin (Adriamycin, Doxil), irinotecan (Camptosar), or thiotepa (Thioplex);
- heart or blood strain remedy similar to atenolol (Tenormin), flecainide (Tambocor), metoprolol (Lopressor, Toprol), propafenone (Rythmol), propranolol (Inderal), and others; or
- HIV or AIDS medication such as efavirenz (Atripla, Sustiva) or ritonavir (Norvir, Kaletra).
This list just isn't full and there are a lot of different medicine that can interact with Wellbutrin. Inform your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not begin a brand new medicine without telling your doctor. Hold a listing of all your medicines and present it to any healthcare provider who treats you. You might have a better threat of seizures if you use sure medications along with Wellbutrin. Tell your physician about all other drugs you use, especially:
- any other antidepressant, or a medication to deal with a psychiatric disorder;
- antihistamines that make you sleepy;
- asthma drugs or bronchodilators;
- contraception tablets or hormone substitute estrogens;
- bladder or urinary drugs resembling oxybutynin (Ditropan, Urotrol);
- antibiotics reminiscent of cefdinir (Omnicef), cephalexin (Keflex), ciprofloxacin (Cipro), amoxicillin (Amoxil, Augmentin), penicillin, and others;
- fat burners, a stimulant, or ADHD treatment similar to Adderall or Ritalin;
- insulin or diabetes medications you take by mouth;
- medicine for nausea, vomiting, or movement sickness;
- drugs to deal with or prevent malaria;
- medicines to treat Parkinson's illness, restless leg syndrome, or pituitary gland tumor (prolactinoma);
- medicines used to forestall organ transplant rejection;
- narcotic pain remedy;
- a sedative similar to diazepam (Valium), and others;
- a steroid equivalent to prednisone, and others;
- avenue drugs akin to "velocity" or cocaine;
- theophylline (Theo-Dur, Slo-Bid, Bronkodyl Theolair, Respbid); or
- ulcer or irritable bowel medications.
Where can I get extra info?
Your pharmacist can present extra information about Wellbutrin.
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